| 23 |
|
|
| 24 |
|
\begin{document} |
| 25 |
|
|
| 26 |
< |
\newcolumntype{A}{p{1.5in}} |
| 27 |
< |
\newcolumntype{B}{p{0.75in}} |
| 28 |
< |
\newcolumntype{C}{p{1.5in}} |
| 29 |
< |
\newcolumntype{D}{p{2in}} |
| 26 |
> |
%\newcolumntype{A}{p{1.5in}} |
| 27 |
> |
%\newcolumntype{B}{p{0.75in}} |
| 28 |
> |
%\newcolumntype{C}{p{1.5in}} |
| 29 |
> |
%\newcolumntype{D}{p{2in}} |
| 30 |
|
|
| 31 |
< |
\newcolumntype{E}{p{0.5in}} |
| 32 |
< |
\newcolumntype{F}{p{1.5in}} |
| 33 |
< |
\newcolumntype{G}{p{3.25in}} |
| 31 |
> |
%\newcolumntype{E}{p{0.5in}} |
| 32 |
> |
%\newcolumntype{F}{p{1.5in}} |
| 33 |
> |
%\newcolumntype{G}{p{3.25in}} |
| 34 |
|
|
| 35 |
< |
\newcolumntype{H}{p{0.75in}} |
| 36 |
< |
\newcolumntype{I}{p{5in}} |
| 35 |
> |
%\newcolumntype{H}{p{0.75in}} |
| 36 |
> |
%\newcolumntype{I}{p{5in}} |
| 37 |
|
|
| 38 |
|
%\renewcommand{\lstlistlistingname}{SCHEMES} |
| 39 |
|
%\renewcommand{\lstlistingname}{Scheme} |
| 53 |
|
\begin{abstract} |
| 54 |
|
|
| 55 |
|
I present a dissertation concerning the structural properties and |
| 56 |
< |
phase behavior of lipid membranes. At first, I investigated the system |
| 57 |
< |
by applying the Monte Carlo simulations on a simple dipolar membrane |
| 58 |
< |
model. Secondly, to obtain the dynamics properties of the ripple phase |
| 59 |
< |
of lipid membranes, molecular dynamics simulations were performed to a |
| 60 |
< |
more realistic molecular lipid model. At last, an algorithm of |
| 61 |
< |
Langevin dynamics was developed to inquire into the ripple phase in |
| 62 |
< |
the implicit solvent environment by working with colleague. |
| 56 |
> |
phase behavior of lipid bilayers. The $P_{\beta'}$ ripple phase, |
| 57 |
> |
named for the periodic buckling of the membrane, is an thermotropic |
| 58 |
> |
phase which develops either from heating the gel phase ($L_{\beta'}$) |
| 59 |
> |
or cooling the fluid phase ($L_\alpha$). This phase typically exhibits |
| 60 |
> |
surface buckling with wavelengths of $100-250$ \AA~and amplitudes of |
| 61 |
> |
$10-50$ \AA. At first, I investigated the system by using Monte Carlo |
| 62 |
> |
simulations on a simple dipolar membrane model. Secondly, to obtain |
| 63 |
> |
the dynamical properties of the ripple phase of lipid membranes, |
| 64 |
> |
molecular dynamics simulations were performed on a more realistic |
| 65 |
> |
molecular-scale lipid model. Finally, an algorithm of Langevin |
| 66 |
> |
dynamics was developed to investigate the ripple phase in an implicit |
| 67 |
> |
solvent environment. |
| 68 |
|
|
| 69 |
|
\end{abstract} |
| 70 |
|
|
| 71 |
|
\begin{dedication} |
| 72 |
|
|
| 73 |
< |
To my wife, for her unconditional support, and to my family, for their |
| 74 |
< |
providence of inspiriting happiness. |
| 73 |
> |
To my wife, for her unconditional support, and to my family, for |
| 74 |
> |
providing inspiration and happiness. |
| 75 |
|
|
| 76 |
|
\end{dedication} |
| 77 |
|
|
| 88 |
|
colleagues Teng Lin, Charles F.~Vardeman II, Shenyu Kuang, Chunlei Li, |
| 89 |
|
Christie Puglis, Patrick Holvey, Matthew A.~Meineke, Christopher |
| 90 |
|
J.~Fennell, Yang Zheng, Kyle Daily, Kyle S.~Haygarth, Jennifer Morton, |
| 91 |
< |
who were always here for technical support and helpful |
| 92 |
< |
suggestions. Finally, I would like to thank my family: my father, |
| 93 |
< |
Jianguo Sun, and my mother, Yumei Lin, for their understanding and |
| 94 |
< |
support on the distant other side of the ocean. And my wife, Yingxin, |
| 95 |
< |
this dissertation could not have been finished without her love. |
| 91 |
> |
who were always here for technical support and helpful suggestions. I |
| 92 |
> |
would also like to thank the members in my advisory commitee, Gregory |
| 93 |
> |
V.~Hartland, S.~Alex Kandel, Steven Corcelli, and Dennis C.~Jacobs for |
| 94 |
> |
their disscusion and review of my dissertation. Finally, I would like |
| 95 |
> |
to thank my family: my father, Jianguo Sun, and my mother, Yumei Lin, |
| 96 |
> |
for their understanding and support on the distant side of the |
| 97 |
> |
world. And my wife, Yingxin, this dissertation could not have been |
| 98 |
> |
finished without her love. |
| 99 |
|
|
| 100 |
|
\end{acknowledge} |
| 101 |
|
|
